Phoenix friends,
This was the main presentation at the AAIC 2025, the Welcome Award presentation.
It comes with some bad news for many of us, but also a lot of hope.
The Bad News First:
- In her study, 100% of patient testing positive for amyloid AND tau develop cognitive impairment issues within 6 years
- By age 70: 50% of E4/E3 carriers and 90% of E4/E4 carriers have brain amyloid
- Women face double vulnerability with inflammation markers
But Here's What Changes Everything:
✅ We have a 15-20 YEAR window to act before symptoms
✅ 45% of our risk is CONTROLLABLE through lifestyle
The Surprises:
Mindfulness is the TOP protective factor (not just exercise!)
Full list of protective factors in the video
Blood pressure meds protect the brain from amyloid
Education delays pathology even with genetic mutations
New DORA sleep drugs change brain proteins in just 36 hours
And quoting Dr. Villeneuve's directly:
"An increased effort needs to be devoted toward finding treatment for APOE4 carriers"
Finally, researchers are calling for treatments designed specifically for US, not generic approaches.
I break down all the conference learnings here:
TAKE ACTION:
Credits: Alzheimer's Association International Conference 2025 Sylvia Villeneuve (McGill University, Canada)
Most Newsletters? One-way street.
How boring…
This is the Phoenix Community after all—so let's make it a two-way street.
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