New data from the Alzheimer's Association APOE Conference (March 2025):

Finding 1: Deleting APOE4 from vascular mural cells (pericytes) restored spatial memory in mice. Zero changes to neurons needed.

Finding 2: Among 1,000+ Brazilian brains studied, APOE4 carriers with high education + social support maintained cognition despite equal plaque burden.

Finding 3: VEGF-R2 drops 45% by age 12-14 months in APOE4 mice. Vascular density follows. This equals your 40s-50s.

Finding 4: APOE4 microglia show 3x higher CD68 expression. Even after complete depletion/repopulation, hyperreactivity persists.

I break down what each finding means for your daily protocol in this video.

→ Watch the full analysis: