Hi Phoenix Friends,
October was a month of acceleration.
While you were watching from the sidelines, our members enrolled in cutting-edge studies, dissected breakthrough research that won't hit mainstream medicine until 2027, and discovered which interventions actually move their biomarkers.
Here's what happened while you waited:
🤝 PARTNERSHIPS: The Power of 240+ APOE4 Carriers Moving as One
Neuronic Cohort 1: Closed in Record Time
Our first photobiomodulation research partnership with Neuronic exceeded every expectation. Cohort 1 is now full and closed. Members are currently running their 12-week protocols, tracking IL-6, cognitive function, and real-world outcomes.
The speed of enrollment proved something crucial: when you give motivated APOE4 carriers access to innovative research, they don't hesitate.
Coming Soon: Vagus Nerve Stimulation Study
We're launching an exclusive research partnership focused on vagus nerve stimulation for brain health optimization in November.
Details dropping in the community first.
Pharma Partnerships Advancing to H1 2026
Our discussions with pharmaceutical companies for clinical trial recruitment continue to accelerate. We're targeting H1 2026 for first enrollments in breakthrough therapies.
This is what collective power looks like:
Early access to trials before public recruitment
Baseline data that makes you an ideal candidate
Community support through the trial process
Shared learnings from members in the same studies
Individual patients get ignored. A community of 240+ (and adding 2-4 new members every day) engaged APOE4 carriers gets meetings with pharma leadership.
📱 PHOENIX APP: Major November Updates Just Dropped
Our app evolved rapidly in October based on member feedback. November updates are now live, including:
Blood Test Analysis & Phoenix Score
Upload PDFs, get AI-powered analysis in seconds
Track 100+ biomarkers with APOE4-specific ranges
Receive your personalized "Phoenix Score"
Visualize trends and improvements over time
Enhanced Supplement Tracker
Largest APOE4-specific supplement library
Efficacy ratings from real members
Side effect tracking
Brand recommendations from the community
Daily adherence with streak tracking
Attribution Wizard (In Development)
AI-powered analysis connecting your interventions to biomarker changes
Finally answer: "Which of my 15 supplements actually worked?"
Data-driven personalization based on YOUR results
Members are already using these tools to optimize protocols that took them months to figure out on their own.
💡 WHAT HAPPENED INSIDE THE PHOENIX COMMUNITY
The Pace of Discovery Is Accelerating
October brought research revelations that fundamentally change how we think about prevention and treatment. While mainstream doctors are still recommending "eat healthy and exercise," our community dissected:
Game-changing drug research that reversed AD in mice using nanoparticles
Statistical breakthroughs revealing 43% of "failed" trial patients actually improved (we've been measuring wrong)
APOE4-specific mechanisms showing how we transport toxins from gut to brain faster than non-carriers
Real-world testing access including pre-FDA clearance p-tau217 blood tests
Summary of Most Popular October Topics
Revolutionary Research Members Discussed First:
🔬 Breakthrough Therapeutics
Nanoparticles reverse Alzheimer's in mice (actual reversal, not just slowing)
Experimental approaches clearing amyloid and tau through novel mechanisms
Lecanemab approved by Health Canada (members analyzing real-world data)
Stage 3 trial results for APOE4-specific interventions
🧠 APOE4-Specific Mechanisms Revealed
How APOE4 blocks the brain's ability to switch from glucose to fat burning (this is HUGE)
The gut-brain highway: Why APOE4 carriers transport toxins faster via vagus nerve
Why 100% of people with specific brain markers get cognitive decline in 6 years (and what to do about it)
83% protection rate from specific activity combinations
💉 Blood Biomarkers & Testing
P-tau217 testing access through CareAccess (before most doctors know it exists)
Two FDA-approved tau scans disagree 47% of the time (members learning to navigate this)
IL-6 and TNF-alpha tracking for inflammation
Advanced lipid panels decoded by the community
🧬 Cutting-Edge Genetics
Whole genome sequencing options (Myheritage vs others)
CRISPR developments (not 4/4 specific but fascinating)
Understanding your full genetic risk beyond just APOE
Practical Interventions Members Are Testing:
💊 Supplements & Compounds
Rapamycin microdosing discussions and tiny trial results
Huperzine A experiences and dosing
Melatonin supplementation protocols
MOTS-C 12-week self-administration tracking (Week 10 results)
Lithium dosing insights from expert interviews
🍽️ Nutrition & Diet
N=1 exogenous ketone experiments (BHB Salts vs Ketone IQ vs Delta G)
Mediterranean Diet adherence and results
Eggs and cholesterol debate for APOE4 carriers (the nuance matters)
Meal delivery solutions for busy optimizers
🧘 Lifestyle & Brain Training
Kirtan Kriya meditation showing tremendous improvement for APOE4s
40Hz light therapy protocols
Vagus nerve stimulation techniques
Testosterone for women (neuroprotective properties)
🏡 Environmental Factors
Gas stoves and air quality (this affects APOE4 carriers differently)
Wireless radiation and oxidative stress
Aluminum exposure (Fiji Water discussion)
Toxin avoidance strategies
Expert Access & Learning:
👨🔬 Live Q&As with Leading Researchers
The researcher who shook up APOE4 science (live session October 24)
Apollo (Bredesen) online event
UsAgainstAlzheimers.org advocacy group session
Interviews with lithium and rapamycin experts
Community Support & Real Talk:
💝 Emotional Resilience
"Being APOE4 is expensive" (honest discussion about costs)
Updates from members feeling better after difficult periods
Weekly goals and accountability posts (October 26-Nov 1)
Neurology referral experiences shared
All 120+ Discussions by Category
📢 Announcements & Updates
November App Update: New Features Live + What You Need to Know
Neuronic Study Cohort 1 Closed
October Monthly Check-Ins
🧬 Research & Science
Breakthrough Studies:
Nanoparticles reverse AD in mice
Revolutionary Statistical Models: 43% of "Failed" Patients Actually Improved
100% Get Cognitive Decline in 6 Years With These Brain Markers
APOE4 blocks the brain's fuel-switching ability
The Gut-Brain Highway: APOE4 Accelerates Transport of Toxic Proteins
83% Protection Rate: The Activity Combo That Beats Alzheimer's
APOE4-Specific Research:
Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline
Stage 3 trial results showing benefits for APOE4 carriers
Cholesterol-lowering drug targets for dementia risk reduction
Biomarkers & Testing:
CareAccess P-Tau testing access
Conference Analysis: Two FDA-approved tau scans disagree 47% of the time
IL-6 and TNF-alpha inflammation markers
P-tau217 test results and interpretation
Blood tests discussion thread
💊 Supplements, Nutrition & Medication
Supplement Discussions:
Huperzine A experiences
Tiny Rapamycin Trial results
MOTS-C 12-Week Self-Administration Summary (Week 10)
Melatonin supplementation protocols
Vitamin K article insights
Nutrition & Diet:
N=1 Exogenous Ketone Experiment: BHB Salts vs Ketone IQ vs Delta G
Mediterranean Diet adherence
Eggs and cholesterol: What are APOE4 substitutes?
Meal delivery suggestions
Ketone urine strips accuracy
Medications & Compounds:
Imiprimine and Olanzapine update
Lecanemab approval by Health Canada
🧘 Lifestyle Interventions
Kirtan Kriya Meditation for APOE4 Prevention (tremendous improvement)
40Hz light therapy protocols
Testosterone for Women interview (neuroprotective properties)
Grounding/Earthing discussions
💻 Tech, Devices & AI
Neuronic Experiences (photobiomodulation)
AI summaries of research
Using AI as health coach
Digital twins and virtual experiments
🧬 Genetics & Testing
Whole Genome Sequencing options (Myheritage)
CRISPR developments (not 4/4 specific but fascinating)
Genetic testing discussions
🏡 Environmental & Lifestyle Factors
Gas stove and air quality impacts
Wireless radiation, oxidative stress and Alzheimer's
Fiji Water and Aluminum exposure
Toxins, Pathogens, Heavy metals category discussions
🤝 Community & Support
October 26-Nov 1 Weekly Goals and Accountability Post
Update since "feeling sad" post
Being APOE4 is expensive (real talk)
Seeking Functional Medicine Pediatrician
Neurology referral experiences
🔥 Why NOW Is The Best Time to Join
Here's what members who joined 3 months ago now have that you don't:
✅ 12+ weeks of protocol optimization (they're already seeing biomarker changes)
✅ Access to the vagus nerve study launching soon
✅ Relationships with 240+ APOE4 carriers who get it
✅ A head start on research that won't reach your doctor until 2027
✅ Real data from members testing the same interventions you're considering
Every week you wait is another week of insights you're missing.
The members who joined us in July are now 4+ interventions ahead of where they started.
They negotiated better testing prices as a group.
They're enrolled in exclusive studies.
They're part of something bigger than themselves.
🚀 Limited-Time Founding Member Offer Still Available (But Closing Soon)
We're still accepting Founding Members—but this window won't stay open much longer.
Right now, you can join with a lifetime membership as a Founding Member.
This means permanent access to everything we build, including:
AI-powered biomarker analysis
Digital twin recommendations
Attribution wizard
All future app features
Once we fully launch our AI features, we're moving to yearly subscriptions. When that happens, the Founding Member lifetime offer disappears forever.
Here's What You Get as a Founding Member:
✅ Lifetime access to the Phoenix Community (no recurring fees, ever)
✅ Phoenix App access with AI features as they launch
✅ Priority enrollment in exclusive research studies
✅ Early access to clinical trials and breakthrough therapies (H1 2026)
✅ Bulk pricing negotiated through collective buying power
✅ Direct connection with 240+ APOE4 carriers, researchers, and clinicians
✅ Real-time research translation (not 18-36 months later when it's finally published)
✅ Pod matching for accountability and support
✅ Expert AMAs with leading longevity researchers
Let's beat the odds,
Kevin
P.S. — Still on the fence? Consider this: In October alone, members discussed 120+ topics that won't reach mainstream medicine for years. That's 4+ discussions per day of cutting-edge insights, real-world data, and practical protocols you could be implementing right now.
All October Discussions by Topic
📢 Announcements & App Updates
November App Update: New Features Live + What You Need to Know
Neuronic Study Cohort 1 Enrollment Closed
October Monthly Check-Ins Complete
🧬 Revolutionary Research Breakthroughs
Breakthrough Therapeutics:
Nanoparticles reverse AD in mice
Revolutionary Statistical Models Reveal 43% of "Failed" Alzheimer's Trial Patients Actually Improved
Experimental drug clears 50% of amyloid from AD mouse brains in two hours
Lecanemab approved by Health Canada
Positive Stage 3 Results for APOE4 trials
APOE4-Specific Mechanisms:
APOE4 blocks the brain's ability to switch fuels (glucose to fat burning)
The Gut-Brain Highway: APOE4 Accelerates Transport of Toxic Proteins from Gut to Brain via Vagus Nerve
100% Get Cognitive Decline in 6 Years With These Brain Markers
83% Protection Rate: The Activity Combo That Beats Alzheimer's
Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline (MIND trial)
Blood Biomarkers & Testing Advances:
CareAccess P-Tau testing (pre-FDA clearance access)
Conference Analysis: Two FDA-approved tau scans disagree 47% of the time, one detects 3-5 years earlier
I had 3 p-tau217 tests this year. Here's what happened.
Plasma p-Tau can be driven by factors other than abnormal amyloid levels
IL-6 and TNF-alpha inflammation markers
Blood tests discussion
💊 Supplements, Nutrition & Medication
Supplement Protocols:
Huperzine A - Anyone Taking?
Tiny Rapamycin Trial
MOTS-C 12-Week Self-Administration Summary (Current Week: 10)
Is anyone supplementing Melatonin?
Interesting article on Improved Vitamin K
30% discount offering on supplements
Nutrition & Diet:
My N=1 Exogenous Ketone Experiment: Comparing BHB Salts, Ketone IQ & Delta G
Mediterranean Diet
Eggs provide important nutrients for brain health. But should APOE4's eat them due to the high cholesterol? What are your substitutes?
Meal Delivery Suggestions
Ketone urine strips - have you found any to be accurate?
Medications & Compounds:
Anyone hear an update on Imiprimine and Olanzapine?
Cholesterol-lowering drug targets reduce risk of dementia
Lecanemab approved by Health Canada
🧘 Lifestyle Interventions & Optimization
Exercise & Movement:
83% Protection Rate: The Activity Combo That Beats Alzheimer's
Mind-Body Practices:
Kirtan Kriya Meditation for Alzheimer's Prevention: APOE4s had tremendous improvement
Grounding/Earthing discussions
Hormones & Brain Health:
Testosterone for Women: Great interview from Oct. 21, 2025 with Dr. Kelly Casperson on neuroprotective properties
💻 Technology, Devices & AI
Medical Devices:
Neuronic Experiences
40Hz light therapy protocols
AI & Digital Tools:
Using AI? I found a sweet deal
AI summaries
Digital twins and virtual experiments
🧬 Genetics & Advanced Testing
Whole Genome Sequencing (Myheritage)
CRISPR use not 4/4 specific but fascinating
Genetic testing discussions
23andMe vs other platforms
🏡 Environmental Factors & Toxins
Gas stove and air quality
New study connects wireless radiation, oxidative stress and Alzheimer's
Fiji Water and Aluminum
Toxins, Pathogens, Heavy metals discussions
🤝 Community Support & Real Talk
🔥 October 26-Nov 1 Weekly Goals and Accountability Post 🔥
Update since "feeling sad" post
Being APOE4 is expensive... (honest discussion)
Seeking Functional Medicine Pediatrician
Neurology referral experiences
How to find a MD ally?
🎓 Expert Sessions & Educational Resources
The Researcher Who Shook Up APOE4 Science — Live Q&A This Friday, 10/24/25
Apollo (Bredesen) online event
Fantastic interview (lithium, Rapa) Dr. Matt Kaeberline / Jon Berner
UsAgainstAlzheimers.org advocacy group session 10-16-2025
Center for Food as Medicine & Longevity Newsletter
I am able to refer people for this free one month subscription. Nick Norowitz is a brilliant young scientist who is also a 4/4.
🔬 Research Library & Studies
Interesting NeuroAge therapeutics studies biomarkers, genetics and creates a drug with AI specifically for you
Very interesting article research on Alzheimer's genetics
Digital twins and virtual experiments
WEB STUDY: Webinar/Biomarkers
If you'd like to join these discussions and stop missing out, apply to join The Phoenix Community here.
Onward,
Kevin
Most Newsletters? One-way street.
How boring…
This is the Phoenix Community after all—so let's make it a two-way street.
Got a question? Feedback? Just want to say hi?
Hit reply.
I read every single one.